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KMID : 0882420100790040438
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Korean Journal of Medicine
2010 Volume.79 No. 4 p.438 ~ p.442
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Sirolimus-induced pneumonitis in a renal transplant recipient
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Kim Jin-Seok
Shin Ah-Young
Kim Jeong-Ho
Kim Eun-Hye
Oak Ju-Hyun
Yang Chul-Woo
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Abstract
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Sirolimus is a promising immunosuppressive agent with low nephrotoxicity and anti-tumor effects; it replaces calcineurin inhibitors, but serious adverse effects have been reported. We report on sirolimus-induced pneumonitis, which is a rare but fatal complication. The patient was a 51-year-old renal transplant recipient who had received sirolimus for 3 months before admission. The patient had a productive cough and mild fever, which began 3 weeks before admission. The chest PA and CT findings were consistent with pneumonia, but a microbiological study and bronchoscopic findings revealed no evidence of infection. Sirolimus-induced pneumonitis was suspected, so the sirolimus was stopped and high-dose steroids were initiated. The respiratory symptoms and radiologic findings improved dramatically after sirolimus withdrawal and the initiation of steroid treatment. These findings strongly suggest a casual relationship between sirolimus and pneumonitis. This is the first case of sirolimus-induced pneumonitis in Korea. (Korean J Med 79:438-442, 2010)
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KEYWORD
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Sirolimus, Renal transplant, Pneumonitis
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